Àìåðèêàíñêèå ó÷åíûå ïîä ðóêîâîäñòâîì Äæîíàòàíà Ïðèò÷àðäà (Jonathan Pritchard) èç ×èêàãñêîãî óíèâåðñèòåòà âûÿâèëè ó÷àñòêè â ãåíîìå ÷åëîâåêà (íàçâàííûå èìè ñèãíàëàìè), êîòîðûå ïîäâåðãëèñü ïîëîæèòåëüíîìó åñòåñòâåííîìó îòáîðó â ñîâñåì íåäàâíåì ïðîøëîì, â ïðîìåæóòêå ìåæäó 5 òûñÿ÷àìè è 15 òûñÿ÷àìè ëåò íàçàä. Äëÿ ýòîãî áûë ðàçðàáîòàí íîâûé àíàëèòè÷åñêèé ìåòîä ñêàíèðîâàíèÿ áàçû äàííûõ ïî îäíîíóêëåîòèäíûì ïîëèìîðôèçìàì, ïîçâîëÿþùèé âûÿâëÿòü ñèãíàëû íåäàâíåãî îòáîðà. Ýòîò ìåòîä áûë èñïîëüçîâàí äëÿ àíàëèçà äàííûõ Ìåæäóíàðîäíîãî ïðîåêòà HapMap ïî ÷àñòîòàì ïîëèìîðôíûõ ãàïëîòèïîâ â òðåõ ðàçëè÷íûõ äåìîãðàôè÷åñêèõ ãðóïïàõ, îòíîñÿùèõñÿ ê Âîñòî÷íîé Àçèè, Åâðîïå è Àôðèêå.  èòîãå áûëî âûÿâëåíî áîëåå ñåìèñîò âîçìîæíûõ ñèãíàëîâ îòáîðà. Áîëüøèíñòâî èç íèõ îêàçàëîñü ðåãèîí-ñïåöèôè÷íûì è ëèøü íåáîëüøîå êîëè÷åñòâî ñèãíàëîâ (÷óòü áîëüøå ñòà) áûëî âûÿâëåíî â äâóõ ãðóïïàõ. Òîëüêî 10 ñèãíàëîâ îòáîðà âûÿâëåíî âî âñåõ òðåõ ãðóïïàõ. Âûÿâëåíèå òàêèõ ñèãíàëîâ ãîâîðèò î ñóùåñòâîâàíèè ãåíåòè÷åñêèõ âàðèàíòîâ ñ ñóùåñòâåííî ðàçëè÷íîé ðåàêöèåé íà ôàêòîðû âíåøíåé ñðåäû è ÿâëÿþùèõñÿ èñòî÷íèêîì ôåíîòèïè÷åñêîé èçìåí÷èâîñòè. Èìåííî ýòè ëîêóñû ïðåäñòàâëÿþò áîëüøîé èíòåðåñ ïðè êàðòèðîâàíèè ñëîæíûõ ïðèçíàêîâ. Àâòîðàìè äëÿ òàêîãî ðîäà èññëåäîâàíèé äëÿ êàæäîé äåìîãðàôè÷åñêîé ãðóïïû áûëè ðàçðàáîòàíû íàáîðû îäíîíóêëåîòèäíûõ ïîëèìîðôèçìîâ äëÿ 250 íàèáîëåå ìîùíûõ ñèãíàëîâ ïîëîæèòåëüíîãî åñòåñòâåííîãî îòáîðà.
http://biology.plosjournals.org/perlserv/?...al.pbio.0040072
êàòåãîðèÿ - 2
 
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[ Âõîä | Ðåãèñòðàöèÿ ]
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Ïîëîæèòåëüíûé îòáîð â ãåíîìå ÷åëîâåêà.
Lady, 21.03.2006 11:23
vrida2, 02.08.2021 08:36
bov12, 02.08.2021 12:29
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bov12, 13.08.2021 18:30
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watchesbiz, 26.08.2021 02:24
watchesbiz, 23.09.2021 06:52
kriz, 21.10.2021 08:05
vrida2, 15.04.2022 08:05
nigoal123, 28.04.2022 11:49
An article is written on a particular theme in a style that makes it suitable for publication in an English-language newspaper, magazine
Always read the instructions for. the task carefully to be clear about on things, so most whom you are writing for.
Always read the instructions for. the task carefully to be clear about on things, so most whom you are writing for.
vrida2, 25.07.2022 00:55
watchesonline89, 03.12.2022 10:00
vrida2, 20.12.2022 16:12
vrida2, 12.01.2024 13:33
Ýòî — ë¸ãêàÿ âåðñèÿ ôîðóìà. ×òîáû ïîïàñòü íà ïîëíóþ, ùåëêíèòå çäåñü.