Èññëåäîâàòåëè èç Boston University School of Medicine âûÿñíèëè, ÷òî ìåñòíîå ïðèìåíåíèå ïðîòèâîÿçâåííûõ ñðåäñòâ çíà÷èòåëüíî óëó÷øàåò ðåçóëüòàòû ëå÷åíèÿ ïåðèîäîíòèòà (âîñïàëåíèå êîðíåâîé îáîëî÷êè çóáîâ è ïðèìûêàþùèõ ê íåé òêàíåé). Ðåçóëüòàòû èññëåäîâàíèÿ îïóáëèêîâàíû â àïðåëüñêîì âûïóñêå Infection and Immunity.
Âîçáóäèòåëåì ïåðèäîíòèòà ÷àñòî ÿâëÿåòñÿ áàêòåðèÿ Porphyromonas gingivalis, êîòîðàÿ íàêàïëèâàåòñÿ â çóáíîì íàë¸òå è âûçûâàåò âîñïàëèòåëüíûå èçìåíåíèÿ â îêðóæàþùåé çóá ñîåäèíèòåëüíîé òêàíè è ìîæåò ïðèâåñòè ê ïîòåðå çóáà. Òîëüêî â ÑØÀ îò ýòîãî çàáîëåâàíèÿ ñòðàäàåò 10 ìèëëèîíîâ ÷åëîâåê.
 ðàáîòå èñïîëüçîâàëñÿ ìîùíûé àíòàãîíèñò H2-ðåöåïòîðîâ ãèñòàìèíà - öèìåòèäèí, êîòîðûé îáû÷íî ïðèìåíÿåòñÿ äëÿ ëå÷åíèÿ ÿçâåííîé áîëåçíè æåëóäêà è äâåíàäöàòèïåðñòíîé êèøêè.  ðàáîòå èñïîëüçîâàëîñü êðîëèêè ñ ýêñïåðèìåíòàëüíûì ïåðèîäîíòèòîì, âûçâàííûì P. gingivalis. Êðîëèêè áûëè ðàçäåëåíû íà ÷åòûðå ãðóïïû. Êðîëèêàì èç òðåõ ãðóïï äëÿ ëå÷åíèÿ ïåðèîäîíòèòà ìåñòíî ïðèìåíÿëñÿ öèìåòèäèí â ðàçëè÷íûõ äîçàõ. Áûëî âûÿâëåíî, ÷òî ìåñòíîå ïðèìåíåíèå öèìåòèäèíà âî âñåõ èñïîëüçîâàííûõ äîçàõ ïîäàâëÿåò âîñïàëèòåëüíûé ïðîöåññ è ïðåäîòâðàùàåò ïîòåðþ çóáà ó 90% êðîëèêîâ.
H. Hasturk, A. Kantarci, N. Ebrahimi, C. Andry, M. Holick, V.L. Jones, T.E. Van Dyke. 2006. Topical H2 antagonist prevents periodontitis in a rabbit model. Infection and Immunity, 74. 4: 2402-2414.
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Ïðîòèâîÿçâåííûå ñðåäñòâà èçëå÷èâàþò áîëåçíè ä¸ñåí
EnTrans, 25.04.2006 18:31
-Vald-, 02.05.2006 09:01
Öèìåòèäèí óæå äàâíî íå ïðèìåíÿåòñÿ äëÿ ëå÷åíèÿ ÿçâåííîé áîëåçíè èç-çà øèðîêîãî ñïåêòðà ñåðüåçíûõ îñëîæíåíèé..
daniil naumoff, 02.05.2006 14:44
10 ìèëëèîíîâ ëþäåé => 10 ìèëëèîíîâ ÷åëîâåê
-Vald-, 03.05.2006 14:56
ñðåäè àíòàãîíèñòîâ Í2-ðåöåïòîðîâ ãèñòàìèíà åñòü ãîðàçäî áîëåå áåçîïàñíûå ïðåïàðàòû (òî æå äåéñòâèòåëüíî øèðîêî èñïîëüçóåìûé ôàìîòèäèí).  öåëîì íå ïîíÿòíî, ïî÷åìó â ðàáîòå èñïîëüçîâàëñÿ èìåííî öèìåòèäèí.. Êðîìå òîãî, õîòåëîñü áû êàêèå-íèáóäü ïîÿñíåíèÿ î ìåõàíèçìàõ äåéñòâèÿ óêàçàííîãî ïðåïàðàòà íà P. gingivalis.
vrida2, 30.01.2022 03:52
vrida2, 15.04.2022 16:25
nigoal123, 28.04.2022 11:48
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vrida2, 25.07.2022 08:28
fashionicon, 25.07.2022 11:23
vrida2, 23.10.2022 22:16
watchesonline89, 04.12.2022 12:10
vrida2, 21.12.2022 02:20
vrida2, 12.01.2024 23:15
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