to klav- Alu - - это ТЕКСТ или СТРУКТУРА ?
to klav - хорошо бы вы как-то пояснили кто текстоструктура

1: Exp Cell Res. 1996 Apr 10;224(1):163-73.Click here to read Links
Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains.
* Haaf T,
* Ward DC.
Max-Planck-Institute of Molecular Genetics, Berlin, Germany.
Fluorescence in situ hybridization and immunofluorescence have been used to visualize specific genomic DNA sequences and proteins in interphase nuclei treated with transcriptional inhibitors. The adenosine analog 5,6-dichloro-beta-D-ribofuranosylbenzimidazole (DRB) and alpha-amanitin selectively inhibit transcription by RNA polymerase II at low doses. Upon exposure to DRB or alpha-amanitin the fibrillar components of the normally compact nucleolus unravel into necklace-like structures which represent highly extended linear arrays of ribosomal ®RNA genes. Similarly, blocks of tandemly repeated satellite DNAs dissociate into extended beaded strands. Localized (euchromatic) chromosome domains and even whole chromosome territories disperse throughout the nuclear interior. Treatment of cells with actinomycin D (AMD) at doses that block rRNA synthesis does not cause significant decondensation of nucleolar, heterochromatic, and interphase chromosome domains. Interestingly, both alpha-amanitin and AMD cause coilin to associate with the nucleolar domain. In AMD-treated cells, coilin is enriched in nucleolar caps abutting upon the residual nucleolus. After alpha-amanitin treatment, coilin is concentrated in numerous beads closely associated with individual rDNA transcription units within nucleolar necklaces. The changes in higher-order nuclear structure are reversible in cell cultures exposed to nontoxic doses of transcriptional inhibitors. It therefore may be concluded that nuclear topographic organization is dependent on a continued transcription of nuclear genes, but not of the rRNA genes.
PMID: 8612682 [PubMed - indexed for MEDLINE]
Related Links
* Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-beta-D-ribofuranosylbenzimidazole. [J Cell Biol. 1984] PMID: 6204996
* 3-D organization of ribosomal transcription units after DRB inhibition of RNA polymerase II transcription. [J Cell Sci. 1999] PMID: 10362544
* The three-dimensional organization of ribosomal genes and the architecture of the nucleoli vary with G1, S and G2 phases. [J Cell Sci. 1995] PMID: 8586655
* Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoter. [J Cell Biol. 2001] PMID: 11448988
* Redistribution of ribosomal DNA after blocking of transcription induced by actinomycin D. [Chromosome Res. 1996] PMID: 8871827
* See all Related Articles...
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to klav - из этого следует что клетка читает ТЕКСТ от нефиг делать - но чтоб
сохранить СТРУКТУРУ

to klav - наверно токо бактерии читают книжки с пользой для себя (транскриптотранслатион) - жизнь научила уму-разуму

2 klav - хорошо бы подождать Геном Саламандры

а из примитивных
организмов типа хамасапиков мало че узнаешь о ДНK

))