Âûñîêîêîíñåðâàòèâíûå íåêîäèðóþùèå ýëåìåíòû ãåíîìà (highly conserved noncoding elements – HCNE) îáû÷íî êëàñòåðèçóþòñÿ â ðàéîíàõ îáåäíåííûõ ãåíàìè âîîáùå, íî îáîãàùåííûìè ãåíàìè òðàíñêðèïöèîííûõ ôàêòîðîâ, ó÷àñòâóþùèõ â ðåãóëÿöèè ðàçâèòèÿ (HOX-êëàñòåðû – ïðèìåð òàêèõ ðàéîíîâ). Àâòîðû ñòàòüè â Cell ñîçäàëè ÷èï íà îñíîâå ïîñëåäîâàòåëüíîñòåé ýòèõ êëàñòåðîâ è ïðîàíàëèçèðîâàëè â ýòèõ ðàéîíàõ ñòàòóñ ìåòèëèðîâàíèÿ ãèñòîíà Í3 ïî 4 ëèçèíó (àêòèâàöèÿ) è ïî 27 ëèçèíó (ðåïðåññèÿ). Îêàçàëîñü, ÷òî òîëüêî â ýìáðèîíàëüíûõ ñòâîëîâûõ êëåòêàõ Í3 ãèñòîíû ãåíîâ, ðàñïîëîæåííûõ ïî ñîñåäñòâó ñ HCNE, íåñóò îáå ìîäèôèêàöèè (!), â îòëè÷èå îò äðóãèõ ïðîàíàëèçèðîâàííûõ (óæå äèôôåðåíöèðîâàííûõ) êëåòîê.  ðàéîíàõ ñ îáåèìè ìåòêàìè ÷àñòî âñòðå÷àþòñÿ CpG-îñòðîâêè è îòñóòñòâóþò òðàíñïîçîíû. Òàêæå â ýòèõ «áèâàëåíòíûõ» ðàéîíàõ ÷àñòî ëîêàëèçóþòñÿ ïëþðîïîòåíòíûå òðàíñêðèïöèîííûå ôàêòîðû Oct4, Sox2 è Nanog. Ñêëàäûâàåòñÿ âïå÷àòëåíèå, áèâàëåíòíûå ðàéîíû ìàðêèðóþò ôóíêöèîíàëüíî âàæíûå òðàíñêðèïöèîííûå ôàêòîðû, çàäåéñòâîâàííûå â ðàçâèòèè, è ïðîïàäàþò â ïðîöåññå äèôôåðåíöèàöèè êëåòîê.
êàòåãîðèÿ - 2
 
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[ Âõîä | Ðåãèñòðàöèÿ ]
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Èçìåíåíèå ìåòèëèðîâàíèÿ ãèñòîíà Í3 â ýìáðèîãåíåçå
Quadrat, 27.04.2006 14:12
vrida2, 30.01.2022 04:24
vrida2, 15.04.2022 16:58
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